[6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling

The anti-cancer outcomes of [6]-gingerol ([6]-GIN), the main active polyphenol of ginger root root (Zingiber officinale), were investigated inside the human bladder cancer cell line 5637. [6]-GIN inhibited cell proliferation, elevated sub-G1 phase ratios, and depolarized mitochondrial membrane potential. [6]-GIN-caused cell dying was connected while using downregulation of B-cell lymphoma 2 (BCL-2) and survivin as well as the upregulation of Bcl-2-connected X protein (Bax). [6]-GIN activated caspase-3 and caspase-9 and controlled the activation of mitogen-activated protein kinases (MAPKs). Further, [6]-GIN also elevated the intracellular reactive oxygen species (ROS) levels and TG100-115 or tranilast elevated [6]-GIN-caused cell dying. These TG100-115 results declare that [6]-GIN caused apoptosis inside the bladder cancer cell line 5637 and so may be used in the development of new drugs for bladder cancer treatment.